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Forbrændingsskade-induceret smerte og depression-lignende adfærd hos mus
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Burn Injury-Induced Pain and Depression-Like Behavior in Mice
DOI:

07:08 min

September 29, 2021

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Chapters

  • 00:04Introduction
  • 00:44Induction of Scalding Burn Injury on the Hind Paw
  • 01:43Measurement of Mechanical Allodynia and Automated Gait Analysis
  • 03:49Measurement of Depression-Like Behavior and Normal Motor Function
  • 04:45Results: Mechanical Allodynia, Gait Analysis, and Depression-Like Behavior in Burn Injury-Induced Mice
  • 06:23Conclusion

Summary

Automatic Translation

En forbigående skoldningsskade (65 °C ± 0,5 °C, 3 s) på den ene bagpote nedsætter tærsklen (g) til von Frey-filamentstimulering af den ipsilaterale side og ændrer gangmønsteret. Desuden inducerer forbrændingsskade depressionslignende adfærd i den tvungne svømmetest.

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