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JoVE Journal Neuroscience
Brug af optogenetik til at vende neuroplasticitet og hæmme kokainsøgning hos rotter
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Brug af optogenetik til at vende neuroplasticitet og hæmme kokainsøgning hos rotter

Article DOI: 10.3791/63185-v • 09:43 min • October 5th, 2021
October 5th, 2021 •
1,2, 1, 1
1Department of Psychiatry, University of Pittsburgh, 2Department of Psychiatry, Rutgers University

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De her beskrevne metoder skitserer en procedure, der anvendes til optogenetisk omvendt kokaininduceret plasticitet i et adfærdsrelevant kredsløb hos rotter. Vedvarende lavfrekvent optisk stimulering af thalamo-amygdala synapser inducerer langvarig depression (LTD). In vivo optogetisk induceret LTD hos kokainerfarne rotter resulterede i den efterfølgende svækkelse af cue-motiveret stofsøgning.

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Neurovidenskab udgave 176 langvarig depression genindsættelse amygdala optogenetik neuromodulation
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