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分析编码人类α突触核蛋白的腺相关病毒载体诱导的帕金森病小鼠模型
JoVE Journal
Neuroscience
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JoVE Journal
Neuroscience
Analyzing the Parkinson’s Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
Please note that all translations are automatically generated.
Click here for the English version.
分析编码人类α突触核蛋白的腺相关病毒载体诱导的帕金森病小鼠模型
DOI:
10.3791/63313-v
•
14:45 min
•
July 29, 2022
•
Daniela Elgueta
,
Ornella Chovar
,
Valentina Ugalde
,
Vanesa Sánchez-Guajardo
,
Alejandra Catenaccio
,
Felipe Court
3,4
,
Rodrigo Pacheco
5
1
Laboratorio de Neuroinmunología
,
Fundación Ciencia & Vida
,
2
Center for Integrative Biology
,
Universidad Mayor
,
3
FONDAP Geroscience Center for Brain Health and Metabolism
,
4
Buck Institute for Research on Ageing
,
5
Facultad de Medicina y Ciencia
,
Universidad San Sebastián
Chapters
00:13
Introduction
02:25
The Stereotaxic Surgery
05:38
Determination of the Motor Performance Using the Beam Test
07:00
Tissue Processing
08:51
Representative Results
12:59
Conclusion
Summary
Automatic Translation
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Automatic Translation
这项工作分析了在这种帕金森病临床前模型中诱导神经炎症,神经变性和运动障碍所需的载体剂量和暴露时间。这些编码人α突触核蛋白的载体被递送到黑质中,以概括与帕金森病相关的突触核蛋白病理学。
Tags
Parkinson’s Disease
Mouse Model
Adeno-associated Viral Vectors
Human α-synuclein
Stereotaxic Delivery
Nigrostriatal Pathway
Neurodegeneration
Neuroinflammation
Motor Impairment
Synuclein Pathology
Microglial Activation
T-cell Activation
Aseptic Environment
Analgesia
Anesthesia
Article
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