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分析编码人类α突触核蛋白的腺相关病毒载体诱导的帕金森病小鼠模型
 
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分析编码人类α突触核蛋白的腺相关病毒载体诱导的帕金森病小鼠模型

Article DOI: 10.3791/63313-v 14:45 min July 29th, 2022
July 29th, 2022

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Summary

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Click here for the English version.

这项工作分析了在这种帕金森病临床前模型中诱导神经炎症,神经变性和运动障碍所需的载体剂量和暴露时间。这些编码人α突触核蛋白的载体被递送到黑质中,以概括与帕金森病相关的突触核蛋白病理学。

Tags

神经科学,第185期,帕金森病,腺相关病毒载体,α突触核蛋白,神经炎症,神经变性,小鼠模型
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