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Induzione e diversi indicatori di valutazione dell'encefalomielite autoimmune sperimentale
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Induzione e diversi indicatori di valutazione dell'encefalomielite autoimmune sperimentale

Article DOI: 10.3791/63866-v • 06:19 min • September 9th, 2022
September 9th, 2022 •
*1, *1, 1,2, 1, 1, 1, 1, 1, 1, 1, 3, 1
1Putuo People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 2National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 3Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University
* These authors contributed equally

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Il presente protocollo descrive l'induzione dell'encefalomielite autoimmune sperimentale in un modello murino utilizzando glicoproteina oligodendrocitaria mielinica e monitorando il processo della malattia utilizzando un sistema di punteggio clinico. I sintomi sperimentali correlati all'encefalomielite autoimmune vengono analizzati utilizzando l'analisi della tomografia microcomputerizzata del femore di topo e il test in campo aperto per valutare il processo della malattia in modo completo.

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Biologia Numero 187 sclerosi multipla encefalomielite autoimmune sperimentale glicoproteina oligodendrocitaria mielinica neuroinfiammazione comportamento ansioso osteoporosi
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