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Induktion og forskellige vurderingsindikatorer for eksperimentel autoimmun encephalomyelitis
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Induktion og forskellige vurderingsindikatorer for eksperimentel autoimmun encephalomyelitis

Article DOI: 10.3791/63866-v • 06:19 min • September 9th, 2022
September 9th, 2022 •
*1, *1, 1,2, 1, 1, 1, 1, 1, 1, 1, 3, 1
1Putuo People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, 2National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 3Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University
* These authors contributed equally

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Den nuværende protokol beskriver induktionen af eksperimentel autoimmun encephalomyelitis i en musemodel ved hjælp af myelin oligodendrocytglykoprotein og overvågning af sygdomsprocessen ved hjælp af et klinisk scoringssystem. Eksperimentelle autoimmune encephalomyelitis-relaterede symptomer analyseres ved hjælp af muselårbensmikrocomputertomografianalyse og åben felttest for at vurdere sygdomsprocessen omfattende.

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Biologi udgave 187 multipel sklerose eksperimentel autoimmun encephalomyelitis myelin oligodendrocytglycoprotein neuroinflammation angstlignende adfærd osteoporose
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