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一套成熟的分析工具，用于研究脂质赋形剂的固态变化
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Chemistry
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JoVE Journal Chemistry
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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一套成熟的分析工具，用于研究脂质赋形剂的固态变化

DOI:
10.3791/63993-v

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11:27 min

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August 09, 2022

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, ,
1Research Center Pharmaceutical Engineering,GmbH, 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy,University of Graz

Chapters

  • 00:04Introduction
  • 01:03Differential Scanning Calorimetry (DSC): Instrument Preparation
  • 02:25Differential Scanning Calorimetry (DSC): Sample Preparation and Measurement
  • 03:00Differential Scanning Calorimetry (DSC): Data Analysis
  • 04:38Small and Wide-Angle X-Ray Scattering (SWAXS)
  • 08:11Results: Correlation Between Solid State Alteration of Lipids and API Release from Different Lipid-Based Dosage Forms
  • 10:39Conclusion

Summary

Automatic Translation

Automatic Translation

该出版物展示了X射线衍射和差示扫描量热法作为研究脂质赋形剂（LBEs）固态的金标准的应用。了解LBEs的固态变化及其对医药产品性能的影响是生产稳健的脂质剂型的关键因素。

Tags

Differential Scanning CalorimetryDSCX-ray DiffractionLipid-based PharmaceuticalsPolymorphismCrystal GrowthSolid-state AlterationLipid MatrixNano Lipid FormulationsMatrix TabletsTemperature ModulationHeating CycleCooling CycleCalibrationSample PreparationAuto Sampler

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