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Journal / Cancer Research / Aloenxertos Ortotópicos Singênicos de Camundongos …
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JoVE Journal Cancer Research
Aloenxertos Ortotópicos Singênicos de Camundongos para Modelo de Câncer de Pâncreas
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Aloenxertos Ortotópicos Singênicos de Camundongos para Modelo de Câncer de Pâncreas

Article DOI: 10.3791/64253-v • 06:20 min • October 4th, 2022
October 4th, 2022 •
1,2,3, 1,2,3,4, *1,2,3, *1,2,3
1Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 2Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 3Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, 4Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich
* These authors contributed equally

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Aloenxertos ortotópicos singênicos de adenocarcinoma ductal pancreático (ADP) de camundongos recapitulam a biologia, os fenótipos e as respostas terapêuticas dos subtipos da doença. Devido à sua rápida e reprodutível progressão tumoral, são amplamente utilizados em estudos pré-clínicos. Aqui, mostramos práticas comuns para gerar esses modelos, injetando culturas de PDAC murino singênico no pâncreas.

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Cancer Research Pâncreas implante ortotópico aloenxerto adenocarcinoma ductal pancreático microambiente tumoral tratamento
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