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JoVE Journal Cancer Research
Syngena ortotopiska allotransplantat för möss för att modellera bukspottskörtelcancer
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Syngena ortotopiska allotransplantat för möss för att modellera bukspottskörtelcancer

Article DOI: 10.3791/64253-v • 06:20 min • October 4th, 2022
October 4th, 2022 •
1,2,3, 1,2,3,4, *1,2,3, *1,2,3
1Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 2Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 3Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, 4Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich
* These authors contributed equally

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Syngena ortotopiska allotransplantat från mus av pankreas duktalt adenokarcinom (PDAC) rekapitulerar biologin, fenotyperna och terapeutiska svaren hos sjukdomssubtyper. På grund av deras snabba, reproducerbara tumörprogression används de ofta i prekliniska studier. Här visar vi vanliga metoder för att generera dessa modeller, injicera syngena murina PDAC-kulturer i bukspottkörteln.

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Cancerforskning Bukspottkörteln ortotopisk implantation allograft pankreas duktalt adenokarcinom tumörmikromiljö behandling
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