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Cancer Research

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JoVE Journal Cancer Research
Syngeneic Mouse Orthotopic allografts å modellere kreft i bukspyttkjertelen
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Syngeneic Mouse Orthotopic allografts å modellere kreft i bukspyttkjertelen

Article DOI: 10.3791/64253-v • 06:20 min • October 4th, 2022
October 4th, 2022 •
1,2,3, 1,2,3,4, *1,2,3, *1,2,3
1Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 2Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 3Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, 4Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich
* These authors contributed equally

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Syngene museortotopiske allotransplantater av pankreasduktalt adenokarsinom (PDAC) rekapitulerer biologi, fenotyper og terapeutiske responser av sykdomssubtyper. På grunn av deres raske, reproduserbare tumorprogresjon, er de mye brukt i prekliniske studier. Her viser vi vanlig praksis for å generere disse modellene, injisere syngene murine PDAC-kulturer i bukspyttkjertelen.

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Kreftforskning utgave 188 Bukspyttkjertel ortotopisk implantasjon allograft pankreasduktalt adenokarsinom tumormikromiljø behandling
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