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JoVE Journal Cancer Research
Syngeneic Mouse Orthotopic Allografts om alvleesklierkanker te modelleren
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Syngeneic Mouse Orthotopic Allografts om alvleesklierkanker te modelleren

Article DOI: 10.3791/64253-v • 06:20 min • October 4th, 2022
October 4th, 2022 •
1,2,3, 1,2,3,4, *1,2,3, *1,2,3
1Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 2Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, 3Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, 4Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich
* These authors contributed equally

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Syngenetische muis orthotopische allografts van pancreas ductaal adenocarcinoom (PDAC) recapituleren de biologie, fenotypen en therapeutische reacties van ziektesubtypen. Vanwege hun snelle, reproduceerbare tumorprogressie worden ze veel gebruikt in preklinische studies. Hier tonen we gemeenschappelijke praktijken om deze modellen te genereren, waarbij syngenetische murine PDAC-culturen in de alvleesklier worden geïnjecteerd.

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Kankeronderzoek Pancreas orthotopische implantatie allograft pancreas ductaal adenocarcinoom tumor micro-omgeving behandeling
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