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Construcción de péptidos cíclicos usando un centro de sulfonio en la correa
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Construcción de péptidos cíclicos usando un centro de sulfonio en la correa

Article DOI: 10.3791/64289-v • 07:11 min • September 28th, 2022
September 28th, 2022 •
*1, *1,2, *1, 3, 1,2, 1, 3, 1,2, 1,2
1Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital, Anhui Medical University
* These authors contributed equally

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Este protocolo presenta la síntesis de péptidos cíclicos a través de la bisalquilación entre cisteína y metionina y la reacción fácil tiol-yne desencadenada por el centro de propargil sulfonio.

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Química Número 187 Péptidos cíclicos bisalquilación/desalquilación bromuro de propargilo estabilización cisteína metionina
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