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使用系绳上的锍中心构建环肽
JoVE Journal
Chemistry
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JoVE Journal
Chemistry
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Please note that all translations are automatically generated.
Click here for the English version.
使用系绳上的锍中心构建环肽
DOI:
10.3791/64289-v
•
07:11 min
•
September 28, 2022
•
Chunli Song*
1
,
Zhanfeng Hou*
1,2
,
Zijun Jiao*
1
,
Zhaodi Liu
,
Chenshan Lian
2
,
Min Zhang
,
Wei Liang
,
Feng Yin
2
,
Zigang Li
2
1
Pingshan Translational Medicine Center
,
Shenzhen Bay Laboratory
,
2
Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology
,
Peking University Shenzhen Graduate School
,
3
Department of Radiation Oncology, the First Affiliated Hospital
,
Anhui Medical University
Chapters
00:04
Introduction
00:38
N-Terminal Fmoc Deprotection
01:36
Coupling the Linear Peptide
02:49
Bisalkylation Between Methionine and Cysteine
04:34
Propargyl Sulfonium Salt Cyclization
05:21
Results: Characterization of the Synthesized Peptides
06:32
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
该协议介绍了通过半胱氨酸和蛋氨酸之间的双烷基化以及由炔丙基锍中心触发的简单硫醇 - 炔反应
合成
环肽。
Tags
Cyclic Peptide
Sulfonium Center
Cysteine
N-terminal Deprotection
Peptide Coupling
Ninhydrin Test
Resin Washing
Trityl-L-cysteine Deprotection
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