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Journal / Cancer Research / 颅内插管植入小鼠连续局部区域嵌合抗原受体（CAR）T细胞输注…
JoVE Journal
Cancer Research

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JoVE Journal Cancer Research
颅内插管植入小鼠连续局部区域嵌合抗原受体（CAR）T细胞输注
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Journal (Cancer Research)
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Determining the Cell Viability of TMEM200A siRNA Transfected HGC-27 Cell Lines Using CCK-8 Assays (Video) | JoVE
Journal (Cancer Research)
Determining the Cell Viability of TMEM200A siRNA Transfected HGC-27 Cell Lines Using CCK-8 Assays (Video) | JoVE
 
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颅内插管植入小鼠连续局部区域嵌合抗原受体（CAR）T细胞输注

Article DOI: 10.3791/64886-v • 05:22 min • February 24th, 2023
February 24th, 2023 •
1, 2,3, 2, 1,2, 1,2, 4,5, 2,3, 2,3, 1,2
1Division of Oncology, Children’s Hospital of Philadelphia, 2Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, 3Division of Neurosurgery, Children’s Hospital of Philadelphia, 4Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, 5Department of Pediatrics, Seattle Children’s Hospital, University of Washington

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中枢神经系统（CNS）肿瘤是儿童癌症相关死亡的主要原因，基于局部免疫的疗法越来越多地在临床试验中为患者进行测试。该协议描述了在小鼠中植入局部区域套管的方法，用于靶向CNS肿瘤的免疫治疗输注的临床前评估。

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