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Journal / Cancer Research / Intrakranielle Kanülenimplantation für serielle…
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Cancer Research

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JoVE Journal Cancer Research
Intrakranielle Kanülenimplantation für serielle lokoregionäre chimäre Antigenrezeptor (CAR) T-Zell-Infusionen in Mäusen
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Intrakranielle Kanülenimplantation für serielle lokoregionäre chimäre Antigenrezeptor (CAR) T-Zell-Infusionen in Mäusen

Article DOI: 10.3791/64886-v • 05:22 min • February 24th, 2023
February 24th, 2023 •
1, 2,3, 2, 1,2, 1,2, 4,5, 2,3, 2,3, 1,2
1Division of Oncology, Children’s Hospital of Philadelphia, 2Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, 3Division of Neurosurgery, Children’s Hospital of Philadelphia, 4Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, 5Department of Pediatrics, Seattle Children’s Hospital, University of Washington

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Tumore des Zentralnervensystems (ZNS) sind die häufigste krebsbedingte Todesursache bei Kindern, und lokoregionäre immunbasierte Therapien werden zunehmend in klinischen Studien an Patienten getestet. Dieses Protokoll beschreibt Methoden zur lokoregionären Kanülenimplantation bei Mäusen zur präklinischen Evaluierung von immuntherapeutischen Infusionen, die auf ZNS-Tumoren abzielen.

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