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Journal / Cancer Research / Intrakraniell kanylimplantation för seriella…
JoVE Journal
Cancer Research

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JoVE Journal Cancer Research
Intrakraniell kanylimplantation för seriella lokoregionala chimära antigenreceptor (CAR) T-cellinfusioner hos möss
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Intrakraniell kanylimplantation för seriella lokoregionala chimära antigenreceptor (CAR) T-cellinfusioner hos möss

Article DOI: 10.3791/64886-v • 05:22 min • February 24th, 2023
February 24th, 2023 •
1, 2,3, 2, 1,2, 1,2, 4,5, 2,3, 2,3, 1,2
1Division of Oncology, Children’s Hospital of Philadelphia, 2Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, 3Division of Neurosurgery, Children’s Hospital of Philadelphia, 4Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, 5Department of Pediatrics, Seattle Children’s Hospital, University of Washington

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Tumörer i centrala nervsystemet (CNS) är den främsta orsaken till cancerrelaterad död hos barn, och lokoregionala immunbaserade terapier testas alltmer för patienter i kliniska prövningar. Detta protokoll beskriver metoder för lokoregional kanylimplantation hos möss för preklinisk utvärdering av immunterapeutiska infusioner riktade mot CNS-tumörer.

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Denna månad i JoVE nummer 192
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