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Journal / Cancer Research / Kwantificering van antilichaamafhankelijke…
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Cancer Research
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JoVE Journal Cancer Research
Kwantificering van antilichaamafhankelijke cellulaire cytotoxiciteit in een tumorsferoïde model
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
Journal (Cancer Research)
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Journal (Cancer Research)
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
 
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Kwantificering van antilichaamafhankelijke cellulaire cytotoxiciteit in een tumorsferoïde model: aanvraag voor ontdekking van geneesmiddelen

Article DOI: 10.3791/65922-v • 13:19 min • April 26th, 2024
April 26th, 2024 •
1,2, 1,3, 1,3, 1, 1,4, 1,4
1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 2Doctoral School of Molecular Medicine, University of Debrecen, 3National Academy of Scientist Education, 4HUN-REN-DE Cell Biology and Signaling Research Group

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Hier presenteren we een methode om verbindingen te identificeren die het ADCC-mechanisme moduleren, een belangrijk kankerceldodend mechanisme van antitumorantilichamen. Het cytotoxische effect van NK-cellen wordt gemeten in sferoïden van borstkankercellen in aanwezigheid van Trastuzumab. Beeldanalyse identificeert levende en dode killer- en doelcellen in sferoïden.

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Kankeronderzoek nummer 206
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