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Journal / Cancer Research / Kvantificering af antistofafhængig cellulær…
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JoVE Journal Cancer Research
Kvantificering af antistofafhængig cellulær cytotoksicitet i en tumorsfæroidmodel
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
Journal (Cancer Research)
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)
Journal (Cancer Research)
Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)
 
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Kvantificering af antistofafhængig cellulær cytotoksicitet i en tumorsfæroidmodel: ansøgning om lægemiddelopdagelse

Article DOI: 10.3791/65922-v • 13:19 min • April 26th, 2024
April 26th, 2024 •
1,2, 1,3, 1,3, 1, 1,4, 1,4
1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 2Doctoral School of Molecular Medicine, University of Debrecen, 3National Academy of Scientist Education, 4HUN-REN-DE Cell Biology and Signaling Research Group

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Her præsenterer vi en metode til at identificere forbindelser, der modulerer ADCC-mekanismen, en vigtig kræftcelledræbende mekanisme af antitumorantistoffer. Den cytotoksiske virkning af NK-celler måles i brystkræftcellesfæroider ved tilstedeværelse af Trastuzumab. Billedanalyse identificerer levende og døde dræber- og målceller i sfæroider.

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Kræftforskning nr. 206
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