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Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model

DOI:
10.3791/3716-v

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09:23 min

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July 29, 2012

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, , ,
1Chagas Disease Multidisciplinary Research Laboratory,University of Brasilia

Chapters

  • 00:05Title
  • 01:04Methods
  • 04:35Results
  • 08:22Conclusions

Summary

Automatic Translation

Automatic Translation

The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.

Tags

Parasite-inducedGenetically-drivenAutoimmuneChagas Heart DiseaseChicken ModelTrypanosoma CruziAcute InfectionsChronic InfectionsChagas DiseaseAutoimmunityParasite PersistenceT. Cruzi InoculationAir ChamberFertilized EggsMature Chicken Immune SystemParasite-free At HatchingParasite Mitochondrial Kinetoplast DNA (kDNA) Minicircle IntegrationTargeted Prime TAIL-PCRSouthern HybridizationsCloningSequencingRuptured Open Reading FramesTranscription FactorsImmune System FactorsPhosphatase (GTPase)Adenylate CyclasePhosphorylases (PKCNF-Kappa B ActivatorPI-3K)MyocarditisRejection Of Target Heart FibersCytotoxic Lymphocytes

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