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Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
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Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols

Article DOI: 10.3791/51258-v • 10:12 min • April 4th, 2014
April 4th, 2014 •
1, 1
1Department of Chemistry, Humboldt University of Berlin

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Summary
Automatic Translation

A novel account for the synthesis of unsymmetrical 1,2-diols based on a retropinacol/cross-pinacol coupling mechanism is described. Due to the catalytic execution of this reaction a considerable improvement compared to conventional cross-pinacol couplings is achieved.

Tags

Retropinacol/Cross-pinacol Coupling Reactions Catalytic Access 1,2-unsymmetrical Diols Reductive Pinacol Coupling Processes Carbonyl Compounds Aldehydes Secondary 1,2-diols Ketones Tertiary 1,2-diols Organic Chemist Fine-tuning Catalytic Direct Pinacol Coupling Process Retropinacol/cross-pinacol Coupling Sequence Substituted 1,2-diols Quantitative Yields Mild Conditions Syringe-pump Techniques Delayed Additions Of Reactants Rapid Access Cross-pinacol Products Vicinal Diols Enantioselective Performance Synthesis
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