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Measurement of the Pressure-volume Curve in Mouse Lungs
 

Measurement of the Pressure-volume Curve in Mouse Lungs

Article DOI: 10.3791/52376-v 09:49 min January 27th, 2015
January 27th, 2015

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Summary

Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.

Tags

Pressure-volume Curve Mouse Lungs Lung Diseases Lung Elasticity Functional Measurements Total Lung Pressure-volume Curve Pulmonary Surfactant Structural Changes Standardized Measurement Method
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