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A Mouse Model of Fatigue Induced by Peripheral Irradiation
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Cancer Research
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JoVE Journal Cancer Research
A Mouse Model of Fatigue Induced by Peripheral Irradiation

A Mouse Model of Fatigue Induced by Peripheral Irradiation

DOI:
10.3791/55145-v

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04:15 min

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March 17, 2017

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, , ,
1Symptom Biology Unit, National Institute of Nursing Research,National Institutes of Health, 2Murine Phenotyping Core, National Heart, Lung, and Blood Institute,National Institutes of Health

Chapters

  • 00:05Title
  • 00:44Running Wheel Acclimation & Baseline
  • 01:49Irradiation & Fatigue Measurement
  • 03:10Results: Irradiated Mice Show Reduced VWRA Compared to Sham
  • 03:42Conclusion

Summary

Automatic Translation

Automatic Translation

We describe a method using targeted peripheral irradiation to induce fatigue-like behavior in mice. The selected non-lethal irradiation dose leads to a week-long reduction in voluntary wheel-running activity.

Tags

Mouse ModelFatiguePeripheral IrradiationVoluntary Wheel-running ActivitySham IrradiationAnesthesiaLead ShieldingRadiation Dose

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