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Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer’s Disease
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Neuroscience
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JoVE Journal Neuroscience
Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer’s Disease

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer’s Disease

DOI:
10.3791/55394-v

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09:38 min

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November 14, 2017

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, , , ,
1Psychiatry and Biobehavioral Sciences,University of California, Los Angeles, 2Biospective, Inc.

Chapters

  • 00:05Title
  • 00:47fMRI BOLD Data Collection & Preprocessing
  • 04:31PPI Model
  • 06:06Group Comparisons
  • 07:34Results: APOEε4 Functional Connectivity Change Maps
  • 08:51Conclusion

Summary

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This manuscript describes how to implement a psychophysiological interaction analysis to reveal task-dependent changes in functional connectivity between a selected seed region and voxels in other regions of the brain. Psychophysiological interaction analysis is a popular method to examine task effects on brain connectivity, distinct from traditional univariate activation effects.

Tags

Alzheimer’s DiseaseFunctional ConnectivityHippocampusMemoryCognitive NeuroscienceGenetic RiskFMRIWords-associative Memory TaskPreprocessingGeneral Linear ModelFEATMotion CorrectionSpatial SmoothingTask Timing

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