Journal
/
/
Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer’s Disease
JoVE Journal
Neuroscience
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Neuroscience
Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer’s Disease
DOI:

09:38 min

November 14, 2017

, , , ,

Chapters

  • 00:05Title
  • 00:47fMRI BOLD Data Collection & Preprocessing
  • 04:31PPI Model
  • 06:06Group Comparisons
  • 07:34Results: APOEε4 Functional Connectivity Change Maps
  • 08:51Conclusion

Summary

Automatic Translation

This manuscript describes how to implement a psychophysiological interaction analysis to reveal task-dependent changes in functional connectivity between a selected seed region and voxels in other regions of the brain. Psychophysiological interaction analysis is a popular method to examine task effects on brain connectivity, distinct from traditional univariate activation effects.

Related Videos

Read Article