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A Simple Neuronal Mechanical Injury Methodology to Study Drosophila Motor Neuron Degeneration
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
A Simple Neuronal Mechanical Injury Methodology to Study Drosophila Motor Neuron Degeneration
DOI:

04:18 min

July 19, 2017

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Chapters

  • 00:05Title
  • 00:41Drosophila Larvae Selection and Preparation
  • 01:30Mechanical Injury and Larvae Treatment
  • 03:16Results: Mechanical Neuronal Injury Enables Temporal Dissection of Neurodegenerative Events
  • 03:53Conclusion

Summary

Automatic Translation

Here we describe a simple and widely accessible method to injure segmental nerves in Drosophila larvae to visualize and quantify neurodegeneration of motor neurons at the neuromuscular junction (NMJ) of third instar larvae.

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