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Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
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JoVE Journal Medicine
Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

DOI:
10.3791/56231-v

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08:34 min

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September 25, 2017

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, , , ,
1Institute of Veterinary Physiology and Zurich Center for Integrative Human Physiology (ZIHP),University of Zurich, 2Laboratoire d’Innovation Thérapeutique, UMR7200,Université de Strasbourg – CNRS, 3Department of Cardiology,Canton Hospital Lucerne

Chapters

  • 00:05Title
  • 01:03Surgery
  • 05:48Results: Representative Transverse Aortic Constriction (TAC) Validation and Analysis
  • 07:07Conclusion

Summary

Automatic Translation

Automatic Translation

The aim of this protocol is to describe step-by-step the technique of minimally invasive transverse aortic constriction (TAC) in mice. By elimination of intubation and ventilation which are mandatory for the commonly used standard procedure, minimally invasive TAC simplifies the operative procedure and reduces the strain put on the animal.

Tags

Minimally InvasiveTransverse Aortic ConstrictionLeft Ventricular HypertrophyMouse ModelSurgical TechniqueAortic ArchPartial SternotomyBlunt DissectionMicrosurgical ForcepsStay SuturesAnesthesiaPostoperative Surveillance

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