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At studere hypothalamus Insulin Signal til perifere glukose Intolerance med en løbende Drug Infusion System ind i musen hjernen
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At studere hypothalamus Insulin Signal til perifere glukose Intolerance med en løbende Drug Infusion System ind i musen hjernen

Article DOI: 10.3791/56410-v • 08:32 min • January 4th, 2018
January 4th, 2018 •
1,2, 1,2,3
1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University

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Denne protokol undersøgelser af chemokine (C-C motiv) ligand 5 (CCL5) i hypothalamus rolle ved at levere en antagonist, MetCCL5, ind i musen hjernen ved hjælp af en mikro-osmotisk pumpe hjernen infusion system. Denne forbigående hæmning af CCL5 aktivitet afbrudt hypothalamus insulin signalering, fører til glukose intolerance og perifere systemisk insulinfølsomhed.

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Medicin sag 131 hjernen medicinafgivelse mikro-osmotisk pumpe insulinresistens glukose metabolisme chemokine (C-C motiv) ligand 5 (CCL5) type 2 diabetes mellitus (T2DM)
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