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Developmental Biology

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JoVE Journal Developmental Biology
Een familiale hypercholesterolemie menselijke lever chimeer muismodel met behulp van geïnduceerde pluripotente stamcel afkomstige hepatocyten
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Een familiale hypercholesterolemie menselijke lever chimeer muismodel met behulp van geïnduceerde pluripotente stamcel afkomstige hepatocyten

Article DOI: 10.3791/57556-v • 10:56 min • September 15th, 2018
September 15th, 2018 •
*1,2,6, *2, *3, 1,2, 2, 2, 4,5, 4,5, 2, 4,5, 4,5, 4,5, 4,5, 3, 4,5,7, 1,2,6,7
1Department of Medicine, University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
* These authors contributed equally

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Hier presenteren we een protocol voor het genereren van een menselijke lever chimeer muismodel van familiale hypercholesterolemie met behulp van menselijke geïnduceerde pluripotente stamcel afkomstige hepatocyten. Dit is een waardevol model voor het testen van nieuwe therapieën voor hypercholesterolemie.

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Ontwikkelingsbiologie kwestie 139 Familial hypercholesterolemie hepatocyten menselijke lever chimeer muizen geïnduceerde pluripotente stamcellen LDL-receptor statines PCSK9 antilichamen
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