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JoVE Journal Cancer Research
Sammenligning metastatisk klar celle renal celle karcinom model etableret i mus nyre og på Kylling Chorioallantoic Membran
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Sammenligning metastatisk klar celle renal celle karcinom model etableret i mus nyre og på Kylling Chorioallantoic Membran

Article DOI: 10.3791/60314-v • 05:36 min • February 8th, 2020
February 8th, 2020 •
*1, *1, 2, 3, 4, 5, 6, 7, 1, 1,8
1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 2Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 3Department of Bioengineering, Hanyang University, 4Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 5Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 6School of Life Sciences, Beijing Normal University, 7Department of Urology, West China Hospital, Sichuan University, 8Department of Urology, David Geffen School of Medicine, University of California, Los Angeles
* These authors contributed equally

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Metastatisk klar celle nyrecelle karcinom er en sygdom uden en omfattende dyremodel for grundig præklinisk undersøgelse. Denne protokol illustrerer to nye dyremodeller for sygdommen: den ortotopisk implanterede musemodel og kyllingchorioallantoic membranmodellen, som begge viser lungemetastase, der ligner kliniske tilfælde.

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Kræftforskning renal celle karcinom metastase dyremodel nyreimplantation CAM VHL gensletning intratumoral heterogenitet
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