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Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase

Article DOI: 10.3791/793-v • 10:21 min • June 16th, 2008
June 16th, 2008 •
1
1Department of Cell Biology and Virology, Heinrich-Pette-Institute for Experimental Virology and Immunology, University of Hamburg

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Current HIV-1 strategies act to suppress the viral life cycle but do not effectively eradicate infection. Here, we demonstrate that an engineered recombinase can efficiently excise integrated HIV-1 proviral DNA from the genome of infected cells.

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HIV-1 Proviral DNA Excision Evolved Recombinase Treatment Strategies Resistant Strains Tre Recombinase LoxLTR Viral Pseudotypes HeLa Cells Virus Production Proof Of Principle
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