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Capsid Proteins: Proteins that form the Capsid of Viruses.

Viral Structure

JoVE 10822

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.

Many criteria are used to classify viruses, including capsid design. Most viruses have icosahedral or helical capsids, although some viruses have developed more complex capsid structures. The icosahedral shape is a 20-sided, quasi-spherical structure. Rhinovirus, the virus that causes the common cold, is icosahedral. Helical (i.e., filamentous or rod-shaped) capsids are thin and linear, resembling cylinders. The nucleic acid genome fits inside the grooves of the helical capsid. Tobacco mosaic virus, a plant pathogen, is a classic example of a helical virus. Some viruses have capsids that are enclosed by an envelope of lipids and proteins outside of the capsid. This viral envelope is not produced by the virus but is acquired from the host’s cell. These envelope molecules protect the virus and mediate interactions with the host’s cells. The viral capsid not only protects the virus’s genome, but it also plays a critical role in interactions with host cells. For i

 Core: Viruses

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

1Department of Molecular Biosciences, University of Texas at Austin, 2School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 3Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 4Department of Microbiology and Immunology, Dalhousie University, 5Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University

JoVE 59920

 Immunology and Infection

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

1Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 2Section on Nervous System Development and Plasticity, The Eunice Kennedy Shriver National Institute of Child and Human Development, National Institutes of Health, 3Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, 4Department of Physiology, Anatomy and Genetics, University of Oxford

JoVE 55724

 Genetics
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