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Studying the Integration of Adult-born Neurons
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Neuroscience
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JoVE Journal Neuroscience
Studying the Integration of Adult-born Neurons

Studying the Integration of Adult-born Neurons

DOI:
10.3791/2548-v

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09:00 min

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March 25, 2011

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, ,
1Department of Neurobiology & Behavior,State University of New York at Stony Brook

Chapters

  • 00:05Title
  • 01:03Introduction
  • 01:35Virus Injection
  • 05:16Electrophysiological Experiments
  • 07:24Results: Identification and Neuronal Activity of Newborn Neurons in the Dentate Gyrus
  • 08:36Conclusion

Summary

Automatic Translation

Automatic Translation

A way to study the integration of newborn dentate granule cells in adult animals is described. This technique uses an engineered retrovirus to label newborn neurons, followed by electrophysiological recordings to determine in vivo functional integration.

Tags

IntegrationAdult-born NeuronsNeurogenesisSub-ventricular ZoneLateral VentricleSub-granular ZoneHippocampal Dentate GyrusBrain DisordersEpilepsySchizophreniaDepressionAnxietyAberrant Neuron IntegrationEtiologyNew TherapiesFate SpecificationMigrationSynaptic IntegrationMaturationGABAergic InputGlutamatergic InputCircuit FormationDentate Granule CellsViral TechniqueCell Birth DateLineageMorphologySynaptogenesis

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