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Implantation af en carotis Cuff til udløsning af shear-stress Induced Åreforkalkning i Mus
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JoVE Journal Medicine
Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Implantation af en carotis Cuff til udløsning af shear-stress Induced Åreforkalkning i Mus

DOI:
10.3791/3308-v

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07:51 min

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January 13, 2012

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, , , , , , , ,
1European Institute for Molecular Imaging,Westfälische Wilhelms-University Münster, 2British Heart Foundation Cardiovascular Sciences Unit,Imperial College London , 3Department of Bioengineering,Imperial College London , 4Biomedical Engineering,Eindhoven University of Technology

Chapters

  • 00:05Title
  • 01:09Preparing the Shear Stress Modifier
  • 01:59Implanting the Cuff Around the Right Carotid Artery
  • 06:35Results: Shear Stress
  • 07:33Conclusion

Summary

Automatic Translation

Automatic Translation

Den snærende manchet præsenteres i denne artikel er designet til at fremkalde åreforkalkning i murine fælles halspulsåren. På grund af den koniske form af dens indre lumen den implanterede manchetten genererer veldefinerede områder med lav, høj og oscillerende shear stress udløser udvikling af aterosklerotiske læsioner af forskellige inflammatoriske fænotyper.

Tags

Carotid CuffShear StressAtherosclerosisInflammatory GenesEndothelial CellsFlow DynamicsSmall Animal ModelsPlaque DevelopmentCarotid Artery LigationEndothelial DysfunctionAtherosclerotic LesionsShear Stress Modifying CuffFluid DynamicsDefined Regions Of Shear StressCommon Carotid ArteryApolipoprotein E (ApoE) Knockout MiceHigh Cholesterol Diet

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