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植入小鼠触发剪应力致动脉粥样硬化的颈袖
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Medicine
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JoVE Journal
Medicine
Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
Please note that all translations are automatically generated.
Click here for the English version.
植入小鼠触发剪应力致动脉粥样硬化的颈袖
DOI:
10.3791/3308-v
•
07:51 min
•
January 13, 2012
•
Michael T. Kuhlmann
,
Simon Cuhlmann
3
,
Irmgard Hoppe
,
Rob Krams
,
Paul C. Evans
,
Gustav J. Strijkers
,
Klaas Nicolay
,
Sven Hermann
,
Michael Schäfers
1
European Institute for Molecular Imaging
,
Westfälische Wilhelms-University Münster
,
2
British Heart Foundation Cardiovascular Sciences Unit
,
Imperial College London
,
3
Department of Bioengineering
,
Imperial College London
,
4
Biomedical Engineering
,
Eindhoven University of Technology
Chapters
00:05
Title
01:09
Preparing the Shear Stress Modifier
01:59
Implanting the Cuff Around the Right Carotid Artery
06:35
Results: Shear Stress
07:33
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
本文介绍的收缩袖口的设计,以诱导小鼠左颈总动脉粥样硬化。由于其内腔的圆锥形植入袖口产生良好定义的低,高和振荡剪切引发动脉粥样硬化病变的不同炎症表型的发展压力的地区。
Tags
Carotid Cuff
Shear Stress
Atherosclerosis
Inflammatory Genes
Endothelial Cells
Flow Dynamics
Small Animal Models
Plaque Development
Carotid Artery Ligation
Endothelial Dysfunction
Atherosclerotic Lesions
Shear Stress Modifying Cuff
Fluid Dynamics
Defined Regions Of Shear Stress
Common Carotid Artery
Apolipoprotein E (ApoE) Knockout Mice
High Cholesterol Diet
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