A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:05Title
- 01:23Induction of Anesthesia
- 02:49Thoracotomy and Heart Preparation
- 04:16Coronary Artery Instrumentation
- 05:19Chest Closure and Myocardial Ischemia and Reperfusion
- 06:56Infarct Size Assessment with Reperfusion Time up to 3 Days
- 09:38Alternative Heart Preparation for Histology
- 11:09Results: The Murine Chronic Closed-chest Model Allows a More Lifelike Approach to Myocardial Ischemia and Reperfusion
- 13:19Conclusion
Chirurgisches Trauma eine entzündliche Reaktion induziert. Zytokine und endogene Liganden bekannt zu modulieren Myokardinfarkt Größe nach Ischämie und Reperfusion. Wir präsentieren eine modifizierte geschlossener Brust Modell der murinen Ischämie und Reperfusion mit hängenden Gewichte zu Auswirkungen der Thorakotomie zu minimieren.
Tags
Murine Closed-chest ModelMyocardial IschemiaReperfusionSurgical TraumaThoracotomyImmune ResponseCytokine ExpressionEndogenous LigandsInnate ImmunityInfarct SizeMyocardial Pre- And PostconditioningHanging WeightsVolatile AnestheticsPreconditioning EffectChronic Closed-chest ModelIntermittent IschemiaMultiple Hit ModelsIntubated MiceVentilated MiceLateral Blunt ThoracotomyLeft Anterior Descending Ligation
