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一种新的手术方法气管内注射生物活性剂在胎鼠模型
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Medicine
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JoVE Journal Medicine
A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
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一种新的手术方法气管内注射生物活性剂在胎鼠模型

DOI:
10.3791/4219-v

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10:12 min

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October 31, 2012

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, , , , , , , , , ,
1Molecular Virology and Gene Therapy,KU Leuven, 2Department of Woman and Child,KU Leuven, 3Neurobiology and Gene Therapy,KU Leuven, 4Division of Nuclear Medicine,KU Leuven, 5Biomedical NMR Unit/ MoSAIC,KU Leuven

Chapters

  • 00:05Title
  • 01:47Fetal Intratracheal Injection
  • 05:07Fetal Intra-amniotic Injection
  • 07:15Representative Fetal Injection Results
  • 09:43Conclusion

Summary

Automatic Translation

Automatic Translation

我们开发了一种新的手术方法气管内给药的生物活性剂的胎鼠。运送路线是更有效地针对胎儿比常用的羊膜腔内注射的小鼠肺组织。这个过程至今没有在小鼠模型中被描述。

Tags

Surgical ApproachIntratracheal AdministrationBioactive AgentsFetal Mouse ModelPrenatal Pulmonary DeliveryTherapeutic StrategiesGenetic DiseasesAcquired DiseasesCongenital AbnormalitiesInherited AbnormalitiesLong-term Gene ExpressionShort-term Gene ExpressionPharmacological InterventionNeonatal Respiratory Distress SyndromeHyperoxic InjuriesCystic Fibrosis (CF)Surfactant Deficienciesα1-antitrypsin DeficiencyPrenatal Gene TherapyEarly Therapeutic InterventionFetal OrgansCell Proliferation RateGene TransferStem Cell Transfer

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