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Models of Bone Metastasis
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JoVE Journal Medicine
Models of Bone Metastasis

Models of Bone Metastasis

DOI:
10.3791/4260-v

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08:49 min

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September 04, 2012

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, , , ,
1Department of Pharmacology,Vanderbilt University, 2Vanderbilt Center for Bone Biology,Vanderbilt University, 3Department of Veterans Affairs,Tennessee Valley Healthcare System (VISN 9), 4Department of Medicine, Division of Clinical Pharmacology,Vanderbilt University, 5Department of Cancer Biology,Vanderbilt University

Chapters

  • 00:05Title
  • 01:22Cell Maintenance and Preparation
  • 02:34Intracardiac Inoculation
  • 04:26Intratibial Injection
  • 06:57Representative Bone Metastasis Results
  • 08:05Conclusion

Summary

Automatic Translation

Automatic Translation

Animal models are frequently utilized to study cancer metastasis to bone. In this protocol we will describe two common methods of tumor inoculation for bone metastasis studies and briefly describe some of the analyses utilized to monitor and quantify these models.

Tags

Bone MetastasisMalignanciesBreast CancerProstate CancerLung CancerMolecular MechanismsTumor GrowthIn Vivo ModelsIntracardiac InoculationAthymic BalbC MicePC-3 Prostate CancerLung CarcinomaMouse Mammary Fat Pad TumorsMDA-MB-231 Breast Cancer ModelGFP ExpressionOsteotropismMetastasis To LungLiverAdrenal GlandsIntratibial InjectionsMammary Fat Pad Injections

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