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Neuroscience

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JoVE Journal Neuroscience
Valutare progressione del ciclo cellulare delle staminali e cellule progenitrici del cervello di sviluppo del mouse dopo stress genotossico
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Valutare progressione del ciclo cellulare delle staminali e cellule progenitrici del cervello di sviluppo del mouse dopo stress genotossico

Article DOI: 10.3791/51209
May 7th, 2014 •
1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Laboratoire de Radiopathologie, CEA DSV iRCM SCSR, 2INSERM, U967, 3Université Paris Diderot, Sorbonne Paris Cité, 4Université Paris Sud, UMR 967

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May 7th, 2014

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La somministrazione di due analoghi della timidina, EdU e BrdU, nei topi in gravidanza permette l'analisi della progressione del ciclo cellulare in cellule progenitrici neurali e nel cervello embrionale mouse. Questo metodo è utile per determinare gli effetti dello stress genotossico, incluse le radiazioni ionizzanti, durante lo sviluppo del cervello.

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