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酰胺偶联反应为双吡啶基配体及其络合合成,以白金为双核抗癌药物
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
DOI:

07:20 min

May 28, 2014

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Chapters

  • 00:05Title
  • 01:22Synthesis of the N,N’-(alkane-1,n-diyl)diisonicotinamide
  • 02:32Purification of the Ligands
  • 03:23Synthesis and Purification of the Dinuclear Platinum Complexes
  • 05:09Results: Characterization of Bispyridine Ligands and Dinuclear Platinum Complexes
  • 06:54Conclusion

Summary

Automatic Translation

这个协议描述了使用异烟酸和二氨基​​烷烃的酰胺偶联反应,以形成适合于在多核铂配合物,其中结合的抗癌药物BBR3464和吡铂方面的合成中使用的桥接配体。

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