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酰胺偶联反应为双吡啶基配体及其络合合成,以白金为双核抗癌药物
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Chemistry
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Please note that all translations are automatically generated.
Click here for the English version.
酰胺偶联反应为双吡啶基配体及其络合合成,以白金为双核抗癌药物
DOI:
10.3791/51740-v
•
07:20 min
•
May 28, 2014
•
Michael G. Apps
,
Ben W. Johnson
,
Oliver B. Sutcliffe
,
Sarah D. Brown
,
Nial J. Wheate
1
Faculty of Pharmacy
,
The University of Sydney
,
2
School of Science and Health
,
University of Western Sydney
,
3
Division of Chemistry and Environmental Science, School of Science and the Environment
,
Manchester Metropolitan University
,
4
Nature Publishing Group
Chapters
00:05
Title
01:22
Synthesis of the
N
,
N’
-(alkane-1,n-diyl)diisonicotinamide
02:32
Purification of the Ligands
03:23
Synthesis and Purification of the Dinuclear Platinum Complexes
05:09
Results: Characterization of Bispyridine Ligands and Dinuclear Platinum Complexes
06:54
Conclusion
Summary
Automatic Translation
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Automatic Translation
这个协议描述了使用异烟酸和二氨基烷烃的酰胺偶联反应,以形成适合于在多核铂配合物,其中结合的抗癌药物BBR3464和吡铂方面的合成中使用的桥接配体。
Tags
Amide Coupling
Bispyridine Ligands
Platinum Anticancer Agents
Dinuclear Complexes
1H NMR
Isonicotinic Acid
Diaminoalkane
Triethylamine
1-propylphosphonic Anhydride
Transplatin
Multinuclear Complexes
Hydrogen Bonding
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