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Medicine
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使用仔猪模型研究麻醉诱发的发育神经毒性(AIDN):一种转化神经科学方法
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal
Medicine
Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach
Please note that all translations are automatically generated.
Click here for the English version.
使用仔猪模型研究麻醉诱发的发育神经毒性(AIDN):一种转化神经科学方法
DOI:
10.3791/55193-v
•
06:38 min
•
June 11, 2017
•
Emmett E. Whitaker
2
,
Christopher Z. Zheng
,
Bruno Bissonnette
2,3
,
Andrew D. Miller
,
Tanner L. Koppert
2
,
Joseph D. Tobias
2
,
Christopher R. Pierson
6
,
Fedias L. Christofi
1
Department of Anesthesiology
,
Ohio State University College of Medicine
,
2
Department of Anesthesiology and Pain Medicine
,
Nationwide Children’s Hospital
,
3
Department of Anaesthesia and Critical Care Medicine
,
University of Toronto
,
4
Department of Biomedical Sciences, Section of Anatomic Pathology
,
Cornell University College of Veterinary Medicine
,
5
Department of Pathology and Anatomy
,
Ohio State University College of Medicine
,
6
Department of Pathology and Laboratory Medicine
,
Nationwide Children’s Hospital
Chapters
00:05
Title
00:45
Preparing the Animal
02:49
Femoral Artery Catheterization
04:11
Collecting Data and Completing Surgery
05:30
Results: Consistency and Reproducibility of Lab Values
06:07
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
麻醉诱导的发育神经毒性(AIDN)研究集中在啮齿动物,其不广泛适用于人类。非人灵长类动物模型更相关,但成本高昂,难以用于实验。相比之下,仔猪是一种临床相关的实用动物模型,是研究麻醉神经毒性的理想选择。
Tags
Piglet Model
Anesthetic-induced Developmental Neurotoxicity (AIDN)
Translational Neuroscience
Physiologic Homeostasis
Anesthesia Induction
Pulse Oximetry
Blood Pressure
Electrocardiography
Temperature
Tracheal Intubation
Lidocaine
End-tidal Carbon Dioxide
Ophthalmic Ointment
Antibiotic
Sterile Field
Femoral Neurovascular Bundle
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