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自组装肽与氨基酸结合的水溶液中疏水性化合物的溶解度
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JoVE Journal Medicine
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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自组装肽与氨基酸结合的水溶液中疏水性化合物的溶解度

DOI:
10.3791/56158-v

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05:08 min

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September 20, 2017

•

, ,
1Latner Thoracic Surgery Research Laboratories,University Health Network, 2Department of Pediatrics,British Columbia Children’s Hospital & University of British Columbia, 3Institute of Medical Science,University of Toronto

Chapters

  • 00:05Title
  • 00:37Preparation of Amino Acid Solutions
  • 01:16Preparation of SAP-AA Solutions
  • 01:56Preparation of Drug-DMSO or Drug-Ethanol Stock Solutions and Drug Formulations
  • 03:11Solubility Testing
  • 03:36Results: Enhancement of Hydrophobic Compound Solubility in Aqueous Solution with Self-assembling Peptide and Amino Acid Solutions
  • 04:16Conclusion

Summary

Automatic Translation

Automatic Translation

本议定书描述了一种临床适用的方法, 溶解疏水化合物在水环境中使用自肽和氨基酸溶液的组合。我们的方法解决疏水疗法的一个主要局限, 缺乏安全, 有效的手段溶解和交付方法入临床设置。

Tags

SolubilityHydrophobic CompoundsAqueous SolutionSelf-assembling PeptideAmino AcidDrug DeliveryCo-solventsDMSOEthanolFormulationVortexSonication

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