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July 27, 2018
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An instrument and methods for the preparation of nanoliter-sized sample volumes for transmission electron microscopy is presented. No paper-blotting steps are required, thus avoiding the detrimental consequences this can have for proteins, significantly reducing sample loss and enabling the analysis of single cell lysate for visual proteomics.
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Cite this Article
Schmidli, C., Rima, L., Arnold, S. A., Stohler, T., Syntychaki, A., Bieri, A., Albiez, S., Goldie, K. N., Chami, M., Stahlberg, H., Braun, T. Miniaturized Sample Preparation for Transmission Electron Microscopy. J. Vis. Exp. (137), e57310, doi:10.3791/57310 (2018).
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