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小鼠用树脂叶毒素和疼痛测试进行脑血管内治疗

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

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小鼠用树脂叶毒素和疼痛测试进行脑血管内治疗

DOI:

10.3791/57570-v

•

06:04 min

•

September 02, 2020

•

Akihiro Fukushima², Moeko Fujii, Hideki Ono²

¹Laboratory of Clinical Pharmacy and Pharmacology,Musashino University, ²Research Institute of Pharmaceutical Sciences,Musashino University

Chapters

00:05Title
00:36Subcutaneous or Intracerebroventricular Injection of RTX
02:02RTX Test
03:11Tail Pressure Test
04:22Results: Nociceptive Responses of Mice that Were Pretreated Subcutaneously or Intracerebroventricularly with RTX
05:37Conclusion

Summary

Automatic Translation

上阴区域的瞬态受体电位瓦尼洛伊德类型1（TRPV1）已被建议在大脑功能中发挥一些作用。此处描述的是用于小鼠超针TRPV1脱敏的树脂叶铁通毒素的针心通泡注射方案。还介绍了一些疼痛测试的程序。

Tags

Intracerebroventricular Resiniferatoxin TRPV1 Desensitization Anesthesia Subcutaneous Injection Paw Withdrawal Tail Pressure Test Nociception Mouse Model Neuropharmalogical Research

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