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Protocol to Create Chronic Wounds in Diabetic Mice

Protocol to Create Chronic Wounds in Diabetic Mice

Article DOI: 10.3791/57656-v 06:55 min September 25th, 2019
September 25th, 2019



Chronic wounds are developed from acute wounds on a diabetic mouse model by inducing high levels of oxidative stress after a full-thickness cutaneous wound. The wound is treated with inhibitors for catalase and glutathione peroxidase, resulting in impaired healing and biofilm development by bacteria present in the skin microbiome.


Chronic Wounds Diabetic Mice Mouse Model Wound Chronicity Medical Field Protocol Hair Clippers Depilatory Lotion Skin Reaction
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