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Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex
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Bioengineering
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JoVE Journal Bioengineering
Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

English

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8,758 Views

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10:42 min

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August 18, 2018

DOI:

10.3791/57829-v

DOI:
10.3791/57829-v

•

10:42 min
August 18, 2018

•

2 Views
, , , , , ,
1Advanced Platform Technology Center, Rehabilitation Research and Development,Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 2Department of Biomedical Engineering,Case Western Reserve University

Summary

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We have shown that a microelectrode implantation in the motor cortex of rats causes immediate and lasting motor deficits. The methods proposed herein outline a microelectrode implantation surgery and three rodent behavioral tasks to elucidate potential changes in the fine or gross motor function due to implantation-caused damage to the motor cortex.

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Cite this Article

Goss-Varley, M., Shoffstall, A. J., Dona, K. R., McMahon, J. A., Lindner, S. C., Ereifej, E. S., Capadona, J. R. Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex. J. Vis. Exp. (138), e57829, doi:10.3791/57829 (2018).

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