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JoVE Journal
Bioengineering

This content is Open Access.

Organotypic Collagen I Assay
 

Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context

Article DOI: 10.3791/3089
October 13th, 2011

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Summary October 13th, 2011

A method is described for the preparation of a 3-dimensional matrix consisting of collagen type I and primary human fibroblasts. This organotypic gel serves as a useful substrate to assess invasive cell migration because it mimics basic features of tissue stroma and is amenable to many forms of microscopy.

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