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Biological Compatibility Profile on Biomaterials for Bone Regeneration
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JoVE Journal Bioengineering
Biological Compatibility Profile on Biomaterials for Bone Regeneration

Biological Compatibility Profile on Biomaterials for Bone Regeneration

DOI:
10.3791/58077-v

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10:28 min

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November 16, 2018

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, , , ,
1Department of Pharmacology and Toxicology,University of Vienna, 2Laboratory of Experimental Allergy, Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology,Medical University of Vienna

Chapters

  • 00:04Title
  • 01:00OB Mineralization Assessed by Staining with Alizarin Red S
  • 03:46Isolation of Bone Marrow OC Precursors for Derivation of Mature OCs
  • 05:01Preparation of Mouse OB-OC Co-culture with Biomaterial
  • 06:03Critical-sized Mouse Calvarial Defect Model
  • 07:40Subchronic Subcutaneous Model
  • 08:18Results: Cell and Tissue Response to Biomaterials for Bone Regeneration
  • 09:54Conclusion

Summary

Automatic Translation

Automatic Translation

The number of novel biomaterials engineered for repairing large bone lesions is continuously expanding with the aim to enhance bone healing and overcome the complications associated with bone transplantation. Here, we present a multidisciplinary strategy for pre-clinical biocompatibility testing of biomaterials for bone repair.

Tags

Keywords: BiomaterialsBone RegenerationBiocompatibilityOsteoblastsAlizarin Red SBeta Tricalcium PhosphateIn VitroIn VivoPreclinical ScreeningOrthopedic BiomaterialsDermatological MethodologyBone HealingMineralizationCetylpyridinium Chloride

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