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JoVE Journal
Immunology and Infection

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建立与艾滋病毒相关的肝脏发病机制的双人性化TK-NOG小鼠模型
 

建立与艾滋病毒相关的肝脏发病机制的双人性化TK-NOG小鼠模型

Article doi: 10.3791/58645
September 11th, 2019

Summary September 11th, 2019

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该协议提供了一种可靠的方法,建立人类免疫系统和肝细胞的人性化小鼠。通过注射人肝细胞和CD34实现的双重组免疫缺陷小鼠造血干细胞易受人体免疫缺陷病毒-1感染和重述肝损伤的影响,如艾滋病毒感染者。

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