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Journal / Biochemistry / 人类外周血神经细胞分离通过评估Rab10磷酸化来询问帕金森氏症相关的LRRK2激酶途径…
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Biochemistry
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JoVE Journal Biochemistry
人类外周血神经细胞分离通过评估Rab10磷酸化来询问帕金森氏症相关的LRRK2激酶途径
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人类外周血神经细胞分离通过评估Rab10磷酸化来询问帕金森氏症相关的LRRK2激酶途径

Article DOI: 10.3791/58956-v • 12:49 min • March 21st, 2020
March 21st, 2020 •
*1, *1, 2, 2, 2, 3, 4, 5, 1, 1,6
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, 2The Michael J. Fox Foundation for Parkinson's Research, 3Department of Medical and Molecular Genetics, Indiana University School of Medicine, 4Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, 5Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, 6Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee
* These authors contributed equally

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Summary
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白氨酸丰富的重复激酶2基因（LRRK2）的突变导致遗传性帕金森病。我们开发了一种简单可靠的方法，用于评估人类外周血中Rab10的LRRK2控制磷酸化。这可能有助于识别具有增加LRRK2激酶通路活性的个人。

Tags

生物化学， 问题 157， 帕金森病， 生物标志物， LRRK2 激酶， 外周血嗜中性粒细胞， Rab蛋白， 囊泡贩运， 蛋白质磷酸化
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