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Pretargeted Radioimmuntherapie basierend auf die Inverse Elektron Nachfrage Diels-Alder-Reaktion
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Pretargeted Radioimmuntherapie basierend auf die Inverse Elektron Nachfrage Diels-Alder-Reaktion

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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Dieses Protokoll beschreibt die Synthese und Charakterisierung von einem Trans- Cyclooctene (TCO)-modifizierte Antikörper und einem 177-Lu-Label kurz (Tz) Radioligand für pretargeted Radioimmuntherapie (Gewinn). Darüber hinaus enthält sie die Verwendung von diesen beiden Konstrukte für in Vivo Bioverteilung und längs Therapiestudien in einem Mausmodell des kolorektalen Karzinoms.

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Chemie Ausgabe 143 Radioimmuntherapie pretargeted Radioimmuntherapie pretargeting inverse Elektron Nachfrage Diels-Alder-Reaktion kurz Trans- Cyclooctene huA33 A33 Antigen Lutetium-177
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