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Pretargeted Radioimmunotherapy baseret på Inverse elektron efterspørgsel Diels-elletræ reaktion
 

Pretargeted Radioimmunotherapy baseret på Inverse elektron efterspørgsel Diels-elletræ reaktion

Article doi: 10.3791/59041
January 29th, 2019

Summary January 29th, 2019

Please note that all translations are automatically generated.

Click here for the English version.

Denne protokol beskriver syntese og karakterisering af en trans- cyclooctene (TCO)-modificeret antistof og en 177Lu-mærket tetrazine (Tz) radioligand for pretargeted radioimmunotherapy (ANNS). Derudover detaljer det brugen af disse to konstruktioner til i vivo biodistribution og langsgående terapi undersøgelser i en murine model af kolorektal cancer.

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