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Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis
JoVE Journal
Medicine
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JoVE Journal Medicine
Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis
DOI:

06:17 min

July 11, 2019

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Chapters

  • 00:04Title
  • 00:33Pre-Surgical Preparation
  • 01:08Clamp and Puncture Site Exposure
  • 02:19Inferior Vena Cava (IVC) Isolation
  • 03:02Aortocaval Fistula (AVF) Creation
  • 03:51IVC Stenosis Creation
  • 04:41Results: Representative Ultrasound Analyses 7 Days Post Surgery
  • 05:48Conclusion

Summary

Automatic Translation

An aortocaval fistula was created by puncturing the murine infra-renal aorta through both walls into the inferior vena cava and was followed by creation of a stenosis in its outflow via partial ligation of the inferior vena cava. This reproducible model can be used to study central venous stenosis.

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